https://scholars.lib.ntu.edu.tw/handle/123456789/634094
標題: | Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve | 作者: | Chen, Szu-Han Wu, Chia-Ching Tseng, Wan-Ling Lu, Fu-I Liu, Ya-Hsin SHAU-PING LIN Lin, Sheng-Che Hsueh, Yuan-Yu |
關鍵字: | adipose derived stem cells; chronic constriction injury; compressive neuropathy; immunomodulation; neuroinflammation; neuropathic pain; stem cell therapy | 公開日期: | 2023 | 卷: | 17 | 來源出版物: | Frontiers in neuroscience | 摘要: | Compressive neuropathy, a common chronic traumatic injury of peripheral nerves, leads to variable impairment in sensory and motor function. Clinical symptoms persist in a significant portion of patients despite decompression, with muscle atrophy and persistent neuropathic pain affecting 10%-25% of cases. Excessive inflammation and immune cell infiltration in the injured nerve hinder axon regeneration and functional recovery. Although adipose-derived stem cells (ASCs) have demonstrated neural regeneration and immunomodulatory potential, their specific effects on compressive neuropathy are still unclear. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634094 | ISSN: | 1662-4548 | DOI: | 10.3389/fnins.2023.1172740 |
顯示於: | 生物科技研究所 |
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