Prognostic value of prostaglandin-endoperoxide synthase 2 polymorphisms in prostate cancer recurrence after radical prostatectomy
Journal
International Journal of Medical Sciences
Journal Volume
13
Journal Issue
9
Pages
696-700
Date Issued
2016
Author(s)
Lee C.-H.
Pao J.-B.
Lu T.-L.
Lee H.-Z.
Lee Y.-C.
Liu C.-C.
Lin V.C.
Yu C.-C.
Yin H.-L.
Huang S.-P.
Bao B.-Y.
Abstract
Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients. Methods: We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy. Results: One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis. Conclusion: Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients. ? Ivyspring International Publisher.
Subjects
Biochemical recurrence; Inflammation; Prostate cancer; PTGS2; Radical prostatectomy; Single-nucleotide polymorphism
SDGs
Other Subjects
cyclooxygenase 2; messenger RNA; prostaglandin synthase; tumor marker; cyclooxygenase 2; PTGS2 protein, human; aged; allele; Article; biochemical recurrence; cancer growth; cancer prognosis; cancer recurrence; controlled study; correlational study; DNA polymorphism; exon; gene; gene expression; gene frequency; gene number; genetic selection; genetic variability; genotype; haplotype; human; intron; major clinical study; male; progression free survival; prostate cancer; prostatectomy; PTGS2 gene; recurrence free survival; single nucleotide polymorphism; treatment outcome; untranslated region; complication; genetic association study; genetics; middle aged; pathology; prognosis; Prostatic Neoplasms; tumor recurrence; Aged; Alleles; Cyclooxygenase 2; Genetic Association Studies; Genotype; Haplotypes; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms
Publisher
Ivyspring International Publisher
Type
journal article