https://scholars.lib.ntu.edu.tw/handle/123456789/584509
標題: | Prognostic value of prostaglandin-endoperoxide synthase 2 polymorphisms in prostate cancer recurrence after radical prostatectomy | 作者: | Lee C.-H. Pao J.-B. Lu T.-L. Lee H.-Z. Lee Y.-C. Liu C.-C. CHAO-YUAN HUANG Lin V.C. Yu C.-C. Yin H.-L. Huang S.-P. Bao B.-Y. |
關鍵字: | Biochemical recurrence; Inflammation; Prostate cancer; PTGS2; Radical prostatectomy; Single-nucleotide polymorphism | 公開日期: | 2016 | 出版社: | Ivyspring International Publisher | 卷: | 13 | 期: | 9 | 起(迄)頁: | 696-700 | 來源出版物: | International Journal of Medical Sciences | 摘要: | Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients. Methods: We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy. Results: One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis. Conclusion: Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients. ? Ivyspring International Publisher. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983638451&doi=10.7150%2fijms.16259&partnerID=40&md5=f63dc2f197cb06bd5eb35a60c6dc1c24 https://scholars.lib.ntu.edu.tw/handle/123456789/584509 |
ISSN: | 1449-1907 | DOI: | 10.7150/ijms.16259 | SDG/關鍵字: | cyclooxygenase 2; messenger RNA; prostaglandin synthase; tumor marker; cyclooxygenase 2; PTGS2 protein, human; aged; allele; Article; biochemical recurrence; cancer growth; cancer prognosis; cancer recurrence; controlled study; correlational study; DNA polymorphism; exon; gene; gene expression; gene frequency; gene number; genetic selection; genetic variability; genotype; haplotype; human; intron; major clinical study; male; progression free survival; prostate cancer; prostatectomy; PTGS2 gene; recurrence free survival; single nucleotide polymorphism; treatment outcome; untranslated region; complication; genetic association study; genetics; middle aged; pathology; prognosis; Prostatic Neoplasms; tumor recurrence; Aged; Alleles; Cyclooxygenase 2; Genetic Association Studies; Genotype; Haplotypes; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms |
顯示於: | 醫學系 |
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