Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis
Journal
Rheumatology International
Journal Volume
34
Journal Issue
5
Pages
625-629
Date Issued
2014
Author(s)
Abstract
Growth arrest-specific protein 6 (Gas6) is a serum protein involved in granulocyte, platelet and endothelium interaction, and is implicated in both anti-inflammatory response as well as platelet/leukocytes activation. We investigated serum Gas6 level in different clinical manifestations of systemic lupus erythematosus (SLE). Data were collected in 83 patients with SLE and 40 non-lupus controls. The Gas6 levels were detected by enzyme-linked immunosorbent assay. Our results demonstrated that the Gas6 level was higher in SLE patients as compared to the non-lupus control subjects (SLE vs. non-lupus control, median [inter-quartile range (IQR)] 22.67 [19.40-28.60] vs. 18.97 [16.05-20.62] ng/mL, p < 0.01). Furthermore, Gas6 level was higher in patients with nephritis (nephritis vs. non-nephritis, median [IQR] 26.21 [21.17-31.61] vs. 22.22 [18.98-26.98] ng/mL, p = 0.03) and in patients with cutaneous vasculitis (vasculitis vs. non-vasculitis, median [IQR] 27.89 [23.24-34.26] vs. 22.30 [19.32-27.16] ng/mL, p = 0.03). Our results indicate that the serum Gas6 level is increased in SLE patients with lupus nephritis or cutaneous vasculitis, implicating a potential to serve as a SLE disease activity marker. ? 2013 Springer-Verlag.
SDGs
Other Subjects
growth arrest specific protein 6; biological marker; growth arrest-specific protein 6; signal peptide; adult; age; alopecia; arthritis; article; controlled study; cutaneous vasculitis; disease activity; disease association; female; fever; human; leukopenia; lupus erythematosus nephritis; major clinical study; male; mouth ulcer; myositis; nephritis; pericarditis; pleurisy; priority journal; protein blood level; SLEDAI; systemic lupus erythematosus; thrombocytopenia; vasculitis; blood; case control study; disease course; Lupus Erythematosus, Systemic; Lupus Nephritis; middle aged; prognosis; upregulation; vasculitis; Adult; Biological Markers; Case-Control Studies; Disease Progression; Female; Humans; Intercellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Middle Aged; Prognosis; Up-Regulation; Vasculitis
Publisher
Springer Verlag
Type
journal article