https://scholars.lib.ntu.edu.tw/handle/123456789/545305
標題: | Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis | 作者: | Wu C.-S. CHUNG-YI HU Tsai H.-F. Chyuan I.-T. Chan C.-J. Chang S.-K. PING-NING HSU |
公開日期: | 2014 | 出版社: | Springer Verlag | 卷: | 34 | 期: | 5 | 起(迄)頁: | 625-629 | 來源出版物: | Rheumatology International | 摘要: | Growth arrest-specific protein 6 (Gas6) is a serum protein involved in granulocyte, platelet and endothelium interaction, and is implicated in both anti-inflammatory response as well as platelet/leukocytes activation. We investigated serum Gas6 level in different clinical manifestations of systemic lupus erythematosus (SLE). Data were collected in 83 patients with SLE and 40 non-lupus controls. The Gas6 levels were detected by enzyme-linked immunosorbent assay. Our results demonstrated that the Gas6 level was higher in SLE patients as compared to the non-lupus control subjects (SLE vs. non-lupus control, median [inter-quartile range (IQR)] 22.67 [19.40-28.60] vs. 18.97 [16.05-20.62] ng/mL, p < 0.01). Furthermore, Gas6 level was higher in patients with nephritis (nephritis vs. non-nephritis, median [IQR] 26.21 [21.17-31.61] vs. 22.22 [18.98-26.98] ng/mL, p = 0.03) and in patients with cutaneous vasculitis (vasculitis vs. non-vasculitis, median [IQR] 27.89 [23.24-34.26] vs. 22.30 [19.32-27.16] ng/mL, p = 0.03). Our results indicate that the serum Gas6 level is increased in SLE patients with lupus nephritis or cutaneous vasculitis, implicating a potential to serve as a SLE disease activity marker. ? 2013 Springer-Verlag. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901341505&doi=10.1007%2fs00296-013-2882-1&partnerID=40&md5=af34fdae5435690ef2628fb9224a7abf https://scholars.lib.ntu.edu.tw/handle/123456789/545305 |
ISSN: | 0172-8172 | DOI: | 10.1007/s00296-013-2882-1 | SDG/關鍵字: | growth arrest specific protein 6; biological marker; growth arrest-specific protein 6; signal peptide; adult; age; alopecia; arthritis; article; controlled study; cutaneous vasculitis; disease activity; disease association; female; fever; human; leukopenia; lupus erythematosus nephritis; major clinical study; male; mouth ulcer; myositis; nephritis; pericarditis; pleurisy; priority journal; protein blood level; SLEDAI; systemic lupus erythematosus; thrombocytopenia; vasculitis; blood; case control study; disease course; Lupus Erythematosus, Systemic; Lupus Nephritis; middle aged; prognosis; upregulation; vasculitis; Adult; Biological Markers; Case-Control Studies; Disease Progression; Female; Humans; Intercellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Middle Aged; Prognosis; Up-Regulation; Vasculitis |
顯示於: | 醫學系 |
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