Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas
Journal
Cancer letters
Journal Volume
201
Journal Issue
1
Pages
97-106
Date Issued
2003
Author(s)
Chen H.-C.
Chu R.Y.
Hsu P.-I.
Lu J.-Y.
Lai K.-H.
Tseng H.-H.
Chou N.-H.
Huang M.-S.
Tseng C.-J.
Hsiao M.
Abstract
Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P<0.001) and expanding type cancer (22%, P<0.001), respectively. The loss of E-cadherin expression was significantly associated with tumor invasion (P<0.05). Furthermore, there was a borderline association between the loss of E-cadherin expression and poor survival (P=0.109). These data demonstrated a striking correlation between E-cadherin expression and the differentiation of gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs. ? 2003 Published by Elsevier Ireland Ltd.
Subjects
Differentiation; E-cadherin; Gastric cancer; Invasion; Prognosis
Other Subjects
uvomorulin; adult; article; cancer classification; cancer infiltration; cancer invasion; cancer survival; cell differentiation; clinical feature; controlled study; correlation analysis; diffusion; disease association; female; histopathology; human; human tissue; immunohistochemistry; intestine cancer; major clinical study; male; medical parameters; metastasis; mucinous carcinoma; papillary carcinoma; priority journal; protein analysis; protein depletion; protein determination; protein expression; protein function; quantitative analysis; signet ring carcinoma; stomach adenocarcinoma; stomach cancer; tumor differentiation
Publisher
Elsevier Ireland Ltd
Type
journal article