https://scholars.lib.ntu.edu.tw/handle/123456789/545351
標題: | Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas | 作者: | Chen H.-C. Chu R.Y. PING-NING HSU Hsu P.-I. Lu J.-Y. Lai K.-H. Tseng H.-H. Chou N.-H. Huang M.-S. Tseng C.-J. Hsiao M. |
關鍵字: | Differentiation; E-cadherin; Gastric cancer; Invasion; Prognosis | 公開日期: | 2003 | 出版社: | Elsevier Ireland Ltd | 卷: | 201 | 期: | 1 | 起(迄)頁: | 97-106 | 來源出版物: | Cancer letters | 摘要: | Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P<0.001) and expanding type cancer (22%, P<0.001), respectively. The loss of E-cadherin expression was significantly associated with tumor invasion (P<0.05). Furthermore, there was a borderline association between the loss of E-cadherin expression and poor survival (P=0.109). These data demonstrated a striking correlation between E-cadherin expression and the differentiation of gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs. ? 2003 Published by Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0142122339&doi=10.1016%2fj.canlet.2003.07.007&partnerID=40&md5=3a7822e6a532981c601ae48b8751335b https://scholars.lib.ntu.edu.tw/handle/123456789/545351 |
ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2003.07.007 | SDG/關鍵字: | uvomorulin; adult; article; cancer classification; cancer infiltration; cancer invasion; cancer survival; cell differentiation; clinical feature; controlled study; correlation analysis; diffusion; disease association; female; histopathology; human; human tissue; immunohistochemistry; intestine cancer; major clinical study; male; medical parameters; metastasis; mucinous carcinoma; papillary carcinoma; priority journal; protein analysis; protein depletion; protein determination; protein expression; protein function; quantitative analysis; signet ring carcinoma; stomach adenocarcinoma; stomach cancer; tumor differentiation |
顯示於: | 醫學系 |
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