Hospital-based surveillance and molecular epidemiology of rotavirus infection in Taiwan, 2005-2007
Journal
Vaccine
Journal Volume
27
Journal Issue
SUPPL. 5
Pages
F50-F54
Date Issued
2009
Author(s)
Abstract
To determine the distribution of rotavirus strains and facilitate vaccine policy decisions in Taiwan, active hospital-based gastroenteritis surveillance was conducted in three sentinel hospitals. From 1 January 2005 to 31 December 2007, a total of 3435 children less than 5 years old with gastroenteritis were enrolled. The presence of rotavirus was documented by enzyme immunoassay (EIA), and the G and P genotypes were determined by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing methods. Results confirmed that 856 (25%) of these gastroenteritis admissions were EIA-positive for rotavirus and 448 (52%) of the rotavirus positive admissions were less than 2 years old. The most prevalent rotavirus genotypes were G1P[8] (40%), followed by strains G3P[8] (27%), and G9P[8] (17%). These data will help inform decisions as to whether rotavirus vaccine should be considered for inclusion into Taiwan's National Immunisation Programme. ? 2009 Elsevier Ltd. All rights reserved.
Subjects
Rotavirus diarrhoea; Seasonality distribution; Strain genotyping
SDGs
Other Subjects
article; child; child hospitalization; disease surveillance; female; gastroenteritis; genotype; human; infant; major clinical study; male; molecular epidemiology; nonhuman; preschool child; prevalence; priority journal; Rotavirus; seasonal variation; Taiwan; virus detection; virus infection; virus strain; Age Distribution; Child, Preschool; Diarrhea; Female; Gastroenteritis; Genotype; Hospitals; Humans; Infant; Male; Molecular Epidemiology; Prevalence; Rotavirus; Rotavirus Infections; Seasons; Sentinel Surveillance; Taiwan
Type
journal article