Safety and efficacy of daptomycin for the treatment of hospitalized adult patients in Taiwan with severe staphylococcal infections
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
45
Journal Issue
1
Pages
52-57
Date Issued
2012
Author(s)
Lai C.-C.
Liao C.-H.
Ho M.-W.
Chen C.-J.
Chen D.-L.
Chou M.-U.
Lee C.-M.
Lin Y.-C.
Pong M.-Y.
Abstract
Background and Purpose: The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied. Methods: A retrospective, multicenter study was performed in Taiwan between December 2007 and June 2009. This study included adult hospitalized patients who had received intravenous daptomycin therapy for infections caused by S aureus. All patients were followed until discharge from the hospital or death. Results: A total of 52 patients (males, n=44; median age: 62 years) were evaluated. Infections included complicated skin and soft-tissue infections (n=14), catheter-related bacteremia (n=14), osteomyelitis and septic arthritis (n=12), endovascular infections and endocarditis (n=11), and urinary tract infections (n=1). Overall, 47 (90.4%) patients were successfully treated and their clinical symptoms were resolved. Adverse effects related to daptomycin were detected in nine patients, but none were required to discontinue daptomycin. Conclusion: The results support daptomycin as an effective and safe treatment for staphylococcal infections in Taiwanese populations. ? 2011.
SDGs
Other Subjects
aminotransferase; creatine kinase; creatinine; daptomycin; fusidic acid; gentamicin; linezolid; polypeptide antibiotic agent; rifampicin; teicoplanin; vancomycin; Acinetobacter infection; adult; aminotransferase blood level; antibiotic sensitivity; article; bacteremia; bacterial arthritis; bacterial strain; bacterium identification; bacterium isolate; broth dilution; candidemia; catheter infection; cause of death; cerebrovascular accident; chronic hepatitis; chronic lung disease; clinical examination; comorbidity; congestive heart failure; coronary artery disease; creatine kinase blood level; creatinine blood level; creatinine clearance; death; diabetes mellitus; disease severity; drug efficacy; drug safety; endocarditis; endovascular infection; Escherichia coli infection; female; follow up; graft septic thrombophlebitis; hemodialysis patient; hospital patient; hospital readmission; human; infection; kidney failure; Klebsiella pneumoniae infection; leukopenia; liver cirrhosis; lung abscess; major clinical study; male; methicillin resistant Staphylococcus aureus infection; microbiological examination; minimum inhibitory concentration; mixed infection; multiple organ failure; myalgia; mycosis; mycotic aortic aneurysm; osteomyelitis; outcome assessment; persistent infection; prosthesis infection; pruritus; Pseudomonas infection; septic shock; side effect; skin infection; soft tissue infection; Staphylococcus infection; Taiwan; thrombophlebitis; treatment duration; treatment failure; treatment response; uremia; urinary tract infection; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Daptomycin; Female; Hospitalization; Humans; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Staphylococcal Infections; Taiwan; Treatment Outcome; Young Adult
Type
journal article