https://scholars.lib.ntu.edu.tw/handle/123456789/536093
標題: | Safety and efficacy of daptomycin for the treatment of hospitalized adult patients in Taiwan with severe staphylococcal infections | 作者: | Lai C.-C. WANG-HUEI SHENG JANN-TAY WANG Liao C.-H. Ho M.-W. Chen C.-J. Chen D.-L. Chou M.-U. Lee C.-M. Lin Y.-C. Pong M.-Y. SHAN-CHWEN CHANG |
公開日期: | 2012 | 卷: | 45 | 期: | 1 | 起(迄)頁: | 52-57 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background and Purpose: The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied. Methods: A retrospective, multicenter study was performed in Taiwan between December 2007 and June 2009. This study included adult hospitalized patients who had received intravenous daptomycin therapy for infections caused by S aureus. All patients were followed until discharge from the hospital or death. Results: A total of 52 patients (males, n=44; median age: 62 years) were evaluated. Infections included complicated skin and soft-tissue infections (n=14), catheter-related bacteremia (n=14), osteomyelitis and septic arthritis (n=12), endovascular infections and endocarditis (n=11), and urinary tract infections (n=1). Overall, 47 (90.4%) patients were successfully treated and their clinical symptoms were resolved. Adverse effects related to daptomycin were detected in nine patients, but none were required to discontinue daptomycin. Conclusion: The results support daptomycin as an effective and safe treatment for staphylococcal infections in Taiwanese populations. ? 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856287557&doi=10.1016%2fj.jmii.2011.09.018&partnerID=40&md5=238821201433cad0af57b74018c928b6 https://scholars.lib.ntu.edu.tw/handle/123456789/536093 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2011.09.018 | SDG/關鍵字: | aminotransferase; creatine kinase; creatinine; daptomycin; fusidic acid; gentamicin; linezolid; polypeptide antibiotic agent; rifampicin; teicoplanin; vancomycin; Acinetobacter infection; adult; aminotransferase blood level; antibiotic sensitivity; article; bacteremia; bacterial arthritis; bacterial strain; bacterium identification; bacterium isolate; broth dilution; candidemia; catheter infection; cause of death; cerebrovascular accident; chronic hepatitis; chronic lung disease; clinical examination; comorbidity; congestive heart failure; coronary artery disease; creatine kinase blood level; creatinine blood level; creatinine clearance; death; diabetes mellitus; disease severity; drug efficacy; drug safety; endocarditis; endovascular infection; Escherichia coli infection; female; follow up; graft septic thrombophlebitis; hemodialysis patient; hospital patient; hospital readmission; human; infection; kidney failure; Klebsiella pneumoniae infection; leukopenia; liver cirrhosis; lung abscess; major clinical study; male; methicillin resistant Staphylococcus aureus infection; microbiological examination; minimum inhibitory concentration; mixed infection; multiple organ failure; myalgia; mycosis; mycotic aortic aneurysm; osteomyelitis; outcome assessment; persistent infection; prosthesis infection; pruritus; Pseudomonas infection; septic shock; side effect; skin infection; soft tissue infection; Staphylococcus infection; Taiwan; thrombophlebitis; treatment duration; treatment failure; treatment response; uremia; urinary tract infection; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Daptomycin; Female; Hospitalization; Humans; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Staphylococcal Infections; Taiwan; Treatment Outcome; Young Adult |
顯示於: | 醫學系 |
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