The flavonoid corylin exhibits lifespan extension properties in mouse
Journal
Nature communications
Journal Volume
13
Journal Issue
1
Date Issued
2022
Author(s)
Wang, Tong-Hong
Tseng, Wei-Che
Leu, Yann-Lii
Chen, Chi-Yuan
Lee, Wen-Chih
Chi, Ying-Chih
Cheng, Shu-Fang
Lai, Chun-Yu
Kuo, Chen-Hsin
Yang, Shu-Ling
Yang, Sien-Hung
Shen, Jiann-Jong
Feng, Chun-Hao
Wu, Chih-Ching
Hwang, Tsong-Long
Wang, Chia-Jen
Chen, Chin-Chuan
Abstract
In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity.
Subjects
CALORIC RESTRICTION; METABOLISM; MTOR; RESVERATROL; ACTIVATORS; ELEGANS; TORC1
SDGs
Publisher
NATURE PORTFOLIO
Type
journal article