https://scholars.lib.ntu.edu.tw/handle/123456789/615975
標題: | The flavonoid corylin exhibits lifespan extension properties in mouse | 作者: | Wang, Tong-Hong Tseng, Wei-Che Leu, Yann-Lii Chen, Chi-Yuan Lee, Wen-Chih Chi, Ying-Chih Cheng, Shu-Fang Lai, Chun-Yu Kuo, Chen-Hsin Yang, Shu-Ling Yang, Sien-Hung Shen, Jiann-Jong Feng, Chun-Hao Wu, Chih-Ching Hwang, Tsong-Long Wang, Chia-Jen SHU-HUEI WANG Chen, Chin-Chuan |
關鍵字: | CALORIC RESTRICTION; METABOLISM; MTOR; RESVERATROL; ACTIVATORS; ELEGANS; TORC1 | 公開日期: | 2022 | 出版社: | NATURE PORTFOLIO | 卷: | 13 | 期: | 1 | 來源出版物: | Nature communications | 摘要: | In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/615975 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-022-28908-2 |
顯示於: | 解剖學暨細胞生物學科所 |
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