The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species
Journal
Medical mycology
Journal Volume
58
Journal Issue
4
Pages
521
Date Issued
2020-06-01
Author(s)
Shen, Mandy
Li, Pei-Tzu
Wu, Yan-Jia
Lin, Ching-Hsuan
Chai, Eric
Chang, Ta-Chau
Chen, Chin-Tin
Abstract
Fungal infections, particularly Candida species, have increased worldwide and caused high morbidity and mortality rates. The toxicity and development of resistance in present antifungal drugs justify the need of new drugs with different mechanism of action. BMVC-12C-P, a carbazole-type compound, has been found to dysfunction mitochondria. BMVC-12C-P displayed the strongest antifungal activities among all of the BMVC derivatives. The minimal inhibitory concentration (MIC) of BMVC-12C-P against Candida species ranged from 1 to 2 μg/ml. Fluconazole-resistant clinical isolates of Candida species were highly susceptible to BMVC-12C-P. The potent fungicidal activity of BMVC-12C-P relates to its impairing mitochondrial function. Furthermore, we found that the hyphae growth and biofilm formation were suppressed in C. albicans survived from BMVC-12C-P treatment. This study demonstrates the potential of BMVC-12C-P as an antifungal agent for treating Candida infections.
Subjects
Candida species; BMVC-12C-P; fungicidal activity; mitochondria
SDGs
Publisher
OXFORD UNIV PRESS
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species.pdf
Size
1.46 MB
Format
Adobe PDF
Checksum
(MD5):3eacd226a9e80478d7b13590e4ee31a8