https://scholars.lib.ntu.edu.tw/handle/123456789/616176
標題: | The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species | 作者: | Shen, Mandy Li, Pei-Tzu Wu, Yan-Jia Lin, Ching-Hsuan Chai, Eric Chang, Ta-Chau Chen, Chin-Tin CHIN-TIN CHEN |
關鍵字: | Candida species; BMVC-12C-P; fungicidal activity; mitochondria | 公開日期: | 1-六月-2020 | 出版社: | OXFORD UNIV PRESS | 卷: | 58 | 期: | 4 | 起(迄)頁: | 521 | 來源出版物: | Medical mycology | 摘要: | Fungal infections, particularly Candida species, have increased worldwide and caused high morbidity and mortality rates. The toxicity and development of resistance in present antifungal drugs justify the need of new drugs with different mechanism of action. BMVC-12C-P, a carbazole-type compound, has been found to dysfunction mitochondria. BMVC-12C-P displayed the strongest antifungal activities among all of the BMVC derivatives. The minimal inhibitory concentration (MIC) of BMVC-12C-P against Candida species ranged from 1 to 2 μg/ml. Fluconazole-resistant clinical isolates of Candida species were highly susceptible to BMVC-12C-P. The potent fungicidal activity of BMVC-12C-P relates to its impairing mitochondrial function. Furthermore, we found that the hyphae growth and biofilm formation were suppressed in C. albicans survived from BMVC-12C-P treatment. This study demonstrates the potential of BMVC-12C-P as an antifungal agent for treating Candida infections. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/616176 | ISSN: | 1369-3786 1460-2709 |
DOI: | 10.1093/mmy/myz071 |
顯示於: | 生化科技學系 |
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The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species.pdf | 1.5 MB | Adobe PDF | 檢視/開啟 |
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