Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy
Journal
Journal of Oral Pathology and Medicine
Journal Volume
34
Journal Issue
4
Pages
253-256
Date Issued
2005
Author(s)
Lee M.-I.
Kuo Y.-S.
Tsai T.
Abstract
Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC. ? Blackwell Munksgaard 2005 · All rights reserved.
SDGs
Other Subjects
aminolevulinic acid; lidocaine; local anesthetic agent; paracetamol; adult; article; cancer recurrence; cancer regression; case report; cigarette smoking; follow up; human; light emitting diode; male; photodynamic therapy; priority journal; treatment outcome; verrucous carcinoma; Administration, Topical; Aminolevulinic Acid; Carcinoma, Verrucous; Dose Fractionation; Follow-Up Studies; Humans; Lip Neoplasms; Male; Middle Aged; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Remission Induction; Treatment Outcome
Type
journal article