https://scholars.lib.ntu.edu.tw/handle/123456789/569200
標題: | Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy | 作者: | HSIN-MING CHEN CHIN-TIN CHEN Yang H. Lee M.-I. YEN-PING KUO Kuo Y.-S. YI-PING WANG Tsai T. CHUN-PIN CHIANG |
公開日期: | 2005 | 卷: | 34 | 期: | 4 | 起(迄)頁: | 253-256 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC. ? Blackwell Munksgaard 2005 · All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-15944392867&doi=10.1111%2fj.1600-0714.2004.00267.x&partnerID=40&md5=35c49fcc87486344bb5bef5c9e0a048c https://scholars.lib.ntu.edu.tw/handle/123456789/569200 |
ISSN: | 0904-2512 | DOI: | 10.1111/j.1600-0714.2004.00267.x | SDG/關鍵字: | aminolevulinic acid; lidocaine; local anesthetic agent; paracetamol; adult; article; cancer recurrence; cancer regression; case report; cigarette smoking; follow up; human; light emitting diode; male; photodynamic therapy; priority journal; treatment outcome; verrucous carcinoma; Administration, Topical; Aminolevulinic Acid; Carcinoma, Verrucous; Dose Fractionation; Follow-Up Studies; Humans; Lip Neoplasms; Male; Middle Aged; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Remission Induction; Treatment Outcome |
顯示於: | 牙醫學系 |
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