Do all the patients with gastric parietal cell antibodies have pernicious anemia?
Journal
Oral Diseases
Journal Volume
19
Journal Issue
4
Pages
381-386
Date Issued
2013
Author(s)
Abstract
Objective: This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA). Materials and Methods: The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and compared with the corresponding data in 124 age- and sex-matched healthy controls. PA was defined by World Health Organization (WHO) as having an Hb concentration < 13 g dl-1 for men and < 12 g dl-1 for women, an MCV ? 100 fl, and a serum vitamin B12 level < 200 pg ml-1. Results: We found that 20, 25, and 20 GPCA-positive patients had deficiencies of Hb (men < 13 g dl-1, women < 12 g dl-1), iron (<60 μg dl-1), and vitamin B12 (<200 pg ml-1), respectively. Moreover, 16 GPCA-positive patients had abnormally high MCV (?100 fl). GPCA-positive patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency and of abnormally high MCV (all P-values < 0.001) than healthy controls. However, only 12.9% of 124 GPCA-positive patients were diagnosed as having PA by the WHO definition. Conclusion: Only 12.9% of GPCA-positive patients are discovered to have PA by the WHO definition. ? 2012 John Wiley & Sons A/S.
Subjects
Gastric parietal cell antibody; Hemoglobin; Iron; Mean corpuscular volume; Pernicious anemia; Vitamin B12
SDGs
Other Subjects
cyanocobalamin; hemoglobin; homocysteine; iron; adult; aged; article; cyanocobalamin deficiency; female; hemoglobin blood level; human; iron blood level; iron deficiency; major clinical study; male; mean corpuscular volume; pernicious anemia; priority journal; stomach parietal cell; Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Antibodies; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Hematinics; Hemoglobins; Homocysteine; Humans; Intrinsic Factor; Iron; Male; Middle Aged; Parietal Cells, Gastric; Sex Factors; Vitamin B 12; World Health Organization; Young Adult
Type
journal article