https://scholars.lib.ntu.edu.tw/handle/123456789/570287
標題: | Do all the patients with gastric parietal cell antibodies have pernicious anemia? | 作者: | Sun A. YI-PING WANG Lin H.P. JEAN-SAN CHIA CHUN-PIN CHIANG |
關鍵字: | Gastric parietal cell antibody; Hemoglobin; Iron; Mean corpuscular volume; Pernicious anemia; Vitamin B12 | 公開日期: | 2013 | 卷: | 19 | 期: | 4 | 起(迄)頁: | 381-386 | 來源出版物: | Oral Diseases | 摘要: | Objective: This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA). Materials and Methods: The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and compared with the corresponding data in 124 age- and sex-matched healthy controls. PA was defined by World Health Organization (WHO) as having an Hb concentration < 13 g dl-1 for men and < 12 g dl-1 for women, an MCV ? 100 fl, and a serum vitamin B12 level < 200 pg ml-1. Results: We found that 20, 25, and 20 GPCA-positive patients had deficiencies of Hb (men < 13 g dl-1, women < 12 g dl-1), iron (<60 μg dl-1), and vitamin B12 (<200 pg ml-1), respectively. Moreover, 16 GPCA-positive patients had abnormally high MCV (?100 fl). GPCA-positive patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency and of abnormally high MCV (all P-values < 0.001) than healthy controls. However, only 12.9% of 124 GPCA-positive patients were diagnosed as having PA by the WHO definition. Conclusion: Only 12.9% of GPCA-positive patients are discovered to have PA by the WHO definition. ? 2012 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876122146&doi=10.1111%2fodi.12014&partnerID=40&md5=a519f49014584638768ee56c49de708c https://scholars.lib.ntu.edu.tw/handle/123456789/570287 |
ISSN: | 1354-523X | DOI: | 10.1111/odi.12014 | SDG/關鍵字: | cyanocobalamin; hemoglobin; homocysteine; iron; adult; aged; article; cyanocobalamin deficiency; female; hemoglobin blood level; human; iron blood level; iron deficiency; major clinical study; male; mean corpuscular volume; pernicious anemia; priority journal; stomach parietal cell; Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Antibodies; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Hematinics; Hemoglobins; Homocysteine; Humans; Intrinsic Factor; Iron; Male; Middle Aged; Parietal Cells, Gastric; Sex Factors; Vitamin B 12; World Health Organization; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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