TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts
Journal
Journal of biomedical science
Journal Volume
31
Journal Issue
1
Date Issued
2024-01-23
Author(s)
Hong, Yi-Kai
Lin, Yu-Chen
Cheng, Tsung-Lin
Lai, Chao-Han
Chang, Yi-Han
Huang, Yu-Lun
Hung, Chia-Yi
Wu, Chen-Han
Hung, Kuo-Shu
Ku, Ya-Chu
Ho, Yen-Ting
Tang, Ming-Jer
Shi, Guey-Yueh
McGrath, John A
Wu, Hua-Lin
Hsu, Chao-Kai
Abstract
Pathologic scars, including keloids and hypertrophic scars, represent a common form of exaggerated cutaneous scarring that is difficult to prevent or treat effectively. Additionally, the pathobiology of pathologic scars remains poorly understood. We aim at investigating the impact of TEM1 (also known as endosialin or CD248), which is a glycosylated type I transmembrane protein, on development of pathologic scars.
Subjects
Fibroblast activation; Hypertrophic scar; Keloid; TEM1/endosialin/CD248; TGF-β
Type
journal article