Safety and immunogenicity of hepatitis A vaccine in healthy children
Journal
Pediatric Infectious Disease Journal
Journal Volume
12
Journal Issue
5
Pages
359-362
Date Issued
1993
Author(s)
Abstract
The immunogenicity and reactogenicity of an inactivated hepatitis A (HA) vaccine in children were investigated. One hundred three healthy children who lacked antibody to HA virus (anti-HA virus), aged between 3 months and 6 years 8 months, were enrolled in this study. They received three doses of 360 enzyme-linked immunosorbent assay units of HA vaccine in a 0-, 1- and 6- month schedule. Blood tests for aminotransferase and anti-HA virus were performed 7 days before and 1, 6 and 7 months after the first dose. Anti-HA virus was tested by radioimmunoassay and also by enzyme immunoassay for titer determination. The seroconversion rates measured by enzyme immunoassay were 95.1% (98 of 103) at Month 1 and 100% at Months 6 and 7. Nine percent (28 of 309) of the injections were followed by local symptoms, usually mild soreness and swelling at the site of injection, and 12% (37 of 309) by minor general symptoms. We conclude that HA vaccine is highly immunogenic and safe in children. It may replace immunoglobulin as an effective method to prevent HA virus infection in children. We also suggest that the HA vaccine be administered to children in endemic areas.
Subjects
Hepatitis A vaccine; immunogenicity; reactogenicity
SDGs
Other Subjects
hepatitis A vaccine; antibody titer; article; dose calculation; drug safety; enzyme linked immunosorbent assay; female; hepatitis A; human; human cell; human tissue; immunogenicity; immunoprophylaxis; injection pain; intramuscular drug administration; major clinical study; male; preschool child; priority journal; seroconversion; vaccination
Type
journal article