https://scholars.lib.ntu.edu.tw/handle/123456789/537258
標題: | Safety and immunogenicity of hepatitis A vaccine in healthy children | 作者: | Horng Y.-C. MEI-HWEI CHANG CHIN-YUN LEE Safary A. Andre F.E. DING-SHINN CHEN |
關鍵字: | Hepatitis A vaccine; immunogenicity; reactogenicity | 公開日期: | 1993 | 卷: | 12 | 期: | 5 | 起(迄)頁: | 359-362 | 來源出版物: | Pediatric Infectious Disease Journal | 摘要: | The immunogenicity and reactogenicity of an inactivated hepatitis A (HA) vaccine in children were investigated. One hundred three healthy children who lacked antibody to HA virus (anti-HA virus), aged between 3 months and 6 years 8 months, were enrolled in this study. They received three doses of 360 enzyme-linked immunosorbent assay units of HA vaccine in a 0-, 1- and 6- month schedule. Blood tests for aminotransferase and anti-HA virus were performed 7 days before and 1, 6 and 7 months after the first dose. Anti-HA virus was tested by radioimmunoassay and also by enzyme immunoassay for titer determination. The seroconversion rates measured by enzyme immunoassay were 95.1% (98 of 103) at Month 1 and 100% at Months 6 and 7. Nine percent (28 of 309) of the injections were followed by local symptoms, usually mild soreness and swelling at the site of injection, and 12% (37 of 309) by minor general symptoms. We conclude that HA vaccine is highly immunogenic and safe in children. It may replace immunoglobulin as an effective method to prevent HA virus infection in children. We also suggest that the HA vaccine be administered to children in endemic areas. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027264087&doi=10.1097%2f00006454-199305000-00001&partnerID=40&md5=0410707233bac277076776f716908c87 https://scholars.lib.ntu.edu.tw/handle/123456789/537258 |
ISSN: | 0891-3668 | DOI: | 10.1097/00006454-199305000-00001 | SDG/關鍵字: | hepatitis A vaccine; antibody titer; article; dose calculation; drug safety; enzyme linked immunosorbent assay; female; hepatitis A; human; human cell; human tissue; immunogenicity; immunoprophylaxis; injection pain; intramuscular drug administration; major clinical study; male; preschool child; priority journal; seroconversion; vaccination |
顯示於: | 醫學系 |
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