Sustained release of insulin from poloxamer gels interpenetrated by polyion complexation of chitosan-hyaluronic acid network
Journal
Biomedical Engineering - Applications, Basis and Communications
Journal Volume
22
Journal Issue
6
Date Issued
2010-12-01
Author(s)
Abstract
This study investigates in vitro the protein drug delivery characteristics of new thermal sensitive gels, poloxamer (P)-chitosan (CS)/hyaluronic acid (HA) gels (P-CS/HA), in which a CS solution is interacting with various concentrations of HA that interpenetrates P gels. The polyion complexation occurs between CS and HA that can protect drugs from proteolysis. The results indicate that the swelling ratios of all P-CS/HA gels are markedly superior to those of nonswelling P and P-CS gels. For example, P-CS/HA (0.5% (w/w)) gels have swelling ratios of 48.3 ± 2.7% (w/w), which are maintained for approximately 0.5 h in water at 37°C. In vitro releases of insulin from P-CS/HA (0.5% (w/w)) gels had significantly lowered initial burst release (P < 0.01) and lasted much longer than those from gels without a CS network. The duration of insulin release was in a significantly sustained manner for up to 3.5 h, which was about two times or longer than the period of delivery using P or P-CS gels. © 2010 National Taiwan University.
Subjects
Insulin | Poloxamer (P)-chitosan (CS)/hyaluronic acid | Polyion complexation
Type
journal article