https://scholars.lib.ntu.edu.tw/handle/123456789/638359
標題: | Sustained release of insulin from poloxamer gels interpenetrated by polyion complexation of chitosan-hyaluronic acid network | 作者: | Yang, Ming Chia Yang, Jiun Sheng YI-YOU HUANG MING-JIUM SHIEH Chung, Tze Wen |
關鍵字: | Insulin | Poloxamer (P)-chitosan (CS)/hyaluronic acid | Polyion complexation | 公開日期: | 1-十二月-2010 | 卷: | 22 | 期: | 6 | 來源出版物: | Biomedical Engineering - Applications, Basis and Communications | 摘要: | This study investigates in vitro the protein drug delivery characteristics of new thermal sensitive gels, poloxamer (P)-chitosan (CS)/hyaluronic acid (HA) gels (P-CS/HA), in which a CS solution is interacting with various concentrations of HA that interpenetrates P gels. The polyion complexation occurs between CS and HA that can protect drugs from proteolysis. The results indicate that the swelling ratios of all P-CS/HA gels are markedly superior to those of nonswelling P and P-CS gels. For example, P-CS/HA (0.5% (w/w)) gels have swelling ratios of 48.3 ± 2.7% (w/w), which are maintained for approximately 0.5 h in water at 37°C. In vitro releases of insulin from P-CS/HA (0.5% (w/w)) gels had significantly lowered initial burst release (P < 0.01) and lasted much longer than those from gels without a CS network. The duration of insulin release was in a significantly sustained manner for up to 3.5 h, which was about two times or longer than the period of delivery using P or P-CS gels. © 2010 National Taiwan University. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638359 | ISSN: | 10162372 | DOI: | 10.4015/S1016237210002298 |
顯示於: | 醫學系 |
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