Anti-CD45 antibody enhances lipoxygenase pathway of human naïve mononuclear cells and cyclooxygenase pathway of neutrophils
Journal
Inflammation research
Journal Volume
55
Journal Issue
3
Pages
92
Date Issued
2006-03
Author(s)
Abstract
Anti-CD45 antibody exhibits multiple biological effects on human mononuclear cells (MNC) and polymorphonuclear neutrophils (PMN). We intended to determine whether anti-CD45 antibody could affect arachidonic acid metabolism and thereby, the interactions between human naïve MNC and PMN.
Subjects
anti-CD45 antibody; arachidonic acid metabolism; leukotriene B-4; prostaglandin E-2; LEUKOCYTE-COMMON ANTIGEN; FC-GAMMA-RIIA; GENE-EXPRESSION; TYROSINE PHOSPHORYLATION; SELECTIVE DEPLETION; MONOCLONAL-ANTIBODY; SIGNAL-TRANSDUCTION; CROSS-LINKING; POLYMORPHONUCLEAR NEUTROPHILS; IMMUNE-RESPONSE
Publisher
SPRINGER BASEL AG
Type
journal article