Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan
Journal
Liver International
Journal Volume
27
Journal Issue
7
Pages
983-988
Date Issued
2007
Author(s)
Abstract
Background: Hepatitis B virus (HBV) genotype C (HBV/C) has two subgenotypes: HBV/Cs and Ce. The prevalence and clinical implications of subgenotype Cs and Ce in Taiwanese HBV carriers remain unknown. Methods: Subgenotypes of HBV/C were determined in 242 Taiwanese HBV carriers with various stages of liver disease. The clinical as well as virologic features between patients with HBV/Cs and HBV/Ce infection were further compared. Results: HBV/Ce was the predominant subgenotype in Taiwan. The prevalence of HBV/Ce was 93.6% in the inactive carriers group, 84.2% in chronic hepatitis patients, 81.2% in cirrhosis patients, 92.5% in hepatocellular carcinoma (HCC) patients without cirrhosis and 91.9% in HCC patients with cirrhosis. There was no significant difference in the distribution of the HBV/C subgenotypes among patients with different stages of liver disease. Conclusions: Subgenotypes of HBV/C may not have a clinical impact on the disease progression of chronic hepatitis B in Taiwan. ? 2007 Blackwell Munksgaard.
SDGs
Other Subjects
hepatitis B surface antigen; adolescent; adult; aged; article; chronic hepatitis; controlled study; disease classification; disease course; disease severity; echography; female; genotype; hepatitis B; Hepatitis B virus; histopathology; human; human tissue; liver cell carcinoma; liver cirrhosis; major clinical study; male; prevalence; single nucleotide polymorphism; Taiwan; virus carrier
Publisher
Blackwell Publishing Ltd
Type
journal article