https://scholars.lib.ntu.edu.tw/handle/123456789/568644
標題: | Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU PEI-JER CHEN Lai M.-Y. Lin C.-L. JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2007 | 出版社: | Blackwell Publishing Ltd | 卷: | 27 | 期: | 7 | 起(迄)頁: | 983-988 | 來源出版物: | Liver International | 摘要: | Background: Hepatitis B virus (HBV) genotype C (HBV/C) has two subgenotypes: HBV/Cs and Ce. The prevalence and clinical implications of subgenotype Cs and Ce in Taiwanese HBV carriers remain unknown. Methods: Subgenotypes of HBV/C were determined in 242 Taiwanese HBV carriers with various stages of liver disease. The clinical as well as virologic features between patients with HBV/Cs and HBV/Ce infection were further compared. Results: HBV/Ce was the predominant subgenotype in Taiwan. The prevalence of HBV/Ce was 93.6% in the inactive carriers group, 84.2% in chronic hepatitis patients, 81.2% in cirrhosis patients, 92.5% in hepatocellular carcinoma (HCC) patients without cirrhosis and 91.9% in HCC patients with cirrhosis. There was no significant difference in the distribution of the HBV/C subgenotypes among patients with different stages of liver disease. Conclusions: Subgenotypes of HBV/C may not have a clinical impact on the disease progression of chronic hepatitis B in Taiwan. ? 2007 Blackwell Munksgaard. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984578691&doi=10.1111%2fj.1478-3231.2007.01546.x&partnerID=40&md5=2c70373d116b13ab421ee0a202bd8d78 https://scholars.lib.ntu.edu.tw/handle/123456789/568644 |
ISSN: | 1478-3223 | DOI: | 10.1111/j.1478-3231.2007.01546.x | SDG/關鍵字: | hepatitis B surface antigen; adolescent; adult; aged; article; chronic hepatitis; controlled study; disease classification; disease course; disease severity; echography; female; genotype; hepatitis B; Hepatitis B virus; histopathology; human; human tissue; liver cell carcinoma; liver cirrhosis; major clinical study; male; prevalence; single nucleotide polymorphism; Taiwan; virus carrier |
顯示於: | 臨床醫學研究所 |
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