The influence of shear stress generated by osmotic driven flow on the alignment of endotheliial cell
Journal
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
ISBN
9781733419017
Date Issued
2020-01-01
Author(s)
Abstract
The complexity of syringe-based or vacuum-driven micropumping requires intricate experimental settings to perform the experiments, consequently diminishing its applicability. Here, we developed a pump-free microfluidic chips to simplify the structure of biochips and improve the flow stability during in situ cell-culture using osmotic pressure. The osmotic pressure drives culture medium smoothly in the microchannel, creating a constant shear stress that endothelial cells experience similarly in human micro-vessels. The aligned arrangements of endothelial cells under tunable shear stress would be presented.
Subjects
Cell arrangement | Osmotic pressure | Shear stress
Type
conference paper