A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient
Journal
Transplant Infectious Disease
Journal Volume
12
Journal Issue
6
Pages
555-560
Date Issued
2010
Author(s)
Abstract
Both bacteremia and biliary cast syndrome are serious post-transplant complications in liver transplant recipients. In the setting of increasing drug resistance in the current era, management of infections caused by multidrug-resistant (MDR) bacteria has proven challenging. We present a case of a liver transplant recipient who developed biliary cast syndrome and intractable MDR Pseudomonas bacteremia that failed to resolve with conventional antimicrobial therapy and which was finally controlled by a novel combination regimen of colistimethate, doripenem, and tobramycin. Future studies validating the clinical efficacy of this combination strategy are warranted. ? 2010 John Wiley & Sons A/S.
SDGs
Other Subjects
ciprofloxacin; colistimethate; doripenem; piperacillin plus tazobactam; prednisone; rifampicin; tacrolimus; tobramycin; adult; antibiotic sensitivity; article; bacteremia; biliary cast syndrome; biliary tract disease; biliary tract drainage; case report; chronic kidney disease; diabetes mellitus; drug withdrawal; follow up; graft recipient; hepatitis C; human; liver cell carcinoma; liver cirrhosis; liver graft; liver graft rejection; liver transplantation; male; multidrug resistance; nonhuman; priority journal; Pseudomonas aeruginosa; renal replacement therapy; retransplantation; Anti-Bacterial Agents; Bacteremia; Bile Duct Diseases; Carbapenems; Colistin; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Humans; Liver Transplantation; Male; Microbial Sensitivity Tests; Middle Aged; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin; Treatment Outcome
Type
journal article