Propylthiouracil-induced antineutrophil cytoplasm antibody-positive anaphylactoid purpura-like vasculitis - A case report
Journal
Journal of the Formosan Medical Association
Journal Volume
99
Journal Issue
8
Pages
642-645
Date Issued
2000
Author(s)
Abstract
Propylthiouracil (PTU), a drug commonly used for treatment of hyperthyroidism, is associated with various rare side effects. Antineutrophil cytoplasm antibody (ANCA)-positive vasculitis is a relatively unusual complication among them. The pathogenesis of ANCA-positive vasculitis during PTU therapy is still obscure. We present the case of a 12-year-old boy who developed ANCA-positive vasculitis during PTU therapy for Graves' disease. His symptoms and signs were indistinguishable from anaphylactoid purpura, a common small-vessel vasculitis in children. The clinical manifestations improved after discontinuation of PTU and immunosuppressant treatment. He remained symptom-free at 11-months follow-up.
Subjects
Antibody; Antineutrophil cytoplasm; Child; Propylthiouracil; Vasculitis
SDGs
Other Subjects
azathioprine; hydroxychloroquine; naproxen; neutrophil cytoplasmic antibody; prednisolone; propylthiouracil; thiamazole; arthritis; article; case report; clinical feature; drug effect; epigastric pain; episcleritis; fever; Graves disease; human; male; microcytic anemia; rash; school child; scleritis; symptom; treatment outcome; vasculitis; Antibodies, Antineutrophil Cytoplasmic; Antithyroid Agents; Child; Graves Disease; Humans; Male; Propylthiouracil; Purpura, Schoenlein-Henoch; Vasculitis
Type
journal article