https://scholars.lib.ntu.edu.tw/handle/123456789/568083
標題: | Propylthiouracil-induced antineutrophil cytoplasm antibody-positive anaphylactoid purpura-like vasculitis - A case report | 作者: | Wang L.-H. Tsai M.-J. WEN-YU TSAI Lee J.-S. BOR-LUEN CHIANG |
關鍵字: | Antibody; Antineutrophil cytoplasm; Child; Propylthiouracil; Vasculitis | 公開日期: | 2000 | 卷: | 99 | 期: | 8 | 起(迄)頁: | 642-645 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Propylthiouracil (PTU), a drug commonly used for treatment of hyperthyroidism, is associated with various rare side effects. Antineutrophil cytoplasm antibody (ANCA)-positive vasculitis is a relatively unusual complication among them. The pathogenesis of ANCA-positive vasculitis during PTU therapy is still obscure. We present the case of a 12-year-old boy who developed ANCA-positive vasculitis during PTU therapy for Graves' disease. His symptoms and signs were indistinguishable from anaphylactoid purpura, a common small-vessel vasculitis in children. The clinical manifestations improved after discontinuation of PTU and immunosuppressant treatment. He remained symptom-free at 11-months follow-up. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033836463&partnerID=40&md5=7f5167db8b0ca21f26de3368598aab8b https://scholars.lib.ntu.edu.tw/handle/123456789/568083 |
ISSN: | 0929-6646 | SDG/關鍵字: | azathioprine; hydroxychloroquine; naproxen; neutrophil cytoplasmic antibody; prednisolone; propylthiouracil; thiamazole; arthritis; article; case report; clinical feature; drug effect; epigastric pain; episcleritis; fever; Graves disease; human; male; microcytic anemia; rash; school child; scleritis; symptom; treatment outcome; vasculitis; Antibodies, Antineutrophil Cytoplasmic; Antithyroid Agents; Child; Graves Disease; Humans; Male; Propylthiouracil; Purpura, Schoenlein-Henoch; Vasculitis |
顯示於: | 醫學系 |
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