Publication:
Neutralizing Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Patients With Central Nervous System and Localized Cryptococcosis: Longitudinal Follow-up and Literature Review

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Date

2022-08-25

Authors

Kuo, Po Hsien
UN-IN WU
Pan, Yi Hua
JANN-TAY WANG
Wang, Yu Chen
HSIN-YUN SUN
WANG-HUEI SHENG
YEE-CHUN CHEN
SHAN-CHWEN CHANG

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Publisher

OXFORD UNIV PRESS INC

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Abstract

Neutralizing anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies (AAbs) have been increasingly recognized to predispose healthy individuals to disseminated cryptococcosis. However, studies have only considered patients with central nervous system (CNS) infection. No longitudinal study has captured the disease spectrum and clinical course.

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Keywords

Cryptococcus gattii; CNS; anti–GM-CSF autoantibodies; cryptococcosis; extraneural

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