Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
Journal
World Journal of Gastrointestinal Oncology
Journal Volume
14
Journal Issue
4
Pages
748-764
Date Issued
2022-04-15
Author(s)
Abstract
The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.
Subjects
Cancer stem cell
Circular rna
Colorectal cancer
Long-non coding rna
Microrna
Regulatory rnas
stemness
SDGs
Publisher
Baishideng Publishing Group Inc
Type
journal article