https://scholars.lib.ntu.edu.tw/handle/123456789/611416
標題: | Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells | 作者: | Chao, Hsiao-Mei Wang, Teh-Wei Edward CHERN SHAN-HUI HSU |
關鍵字: | Cancer stem cell;Circular rna;Colorectal cancer;Long-non coding rna;Microrna;Regulatory rnas;stemness | 公開日期: | 15-四月-2022 | 出版社: | Baishideng Publishing Group Inc | 卷: | 14 | 期: | 4 | 起(迄)頁: | 748-764 | 來源出版物: | World Journal of Gastrointestinal Oncology | 摘要: | The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/611416 | ISSN: | 19485204 | DOI: | 10.4251/wjgo.v14.i4.748 |
顯示於: | 生化科技學系 |
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