Associations between high-sensitivity C-reactive protein and non-communicable diseases in an Asian population: findings from the IFLS study

Background: There has been no comprehensive study on how high-sensitivity C-reactive protein (hs-CRP) levels, a biomarker of inflammation, are associated with subsequent diagnoses of various non-communicable diseases (NCDs) in Asians. Our study is the first to do so to better compare these associations in an Asian population.Methods: This is a nationwide longitudinal study of 3,410 male and 4,004 female participants of the RAND Indonesian Family Life Survey with a mean age of 42.4 years, to examine associations between increasing hs-CRP levels and risks of heart diseases, stroke, hypertension, diabetes, arthritis, non-cancerous stomach or other digestive diseases, and non-cancerous kidney diseases. We used unadjusted and confounding-adjusted weighted Poisson regression models to respectively examine associations involving hs-CRP as a risk predictor or indicator of chronic inflammation. Several stratified subpopulation analyses were also performed.Results: Increasing hs-CRP levels predicted significantly higher risks of being diagnosed with all of the studied NCDs except stomach or other digestive diseases. After adjusting for confounding, increasing hs-CRP levels were significantly associated with higher risks of diabetes, heart diseases, hypertension, and kidney diseases.Conclusions: Our comprehensive findings on the associations between hs-CRP levels and risks of several NCDs in Asians may have clinical implications and promote additional studies on this topic.