https://scholars.lib.ntu.edu.tw/handle/123456789/586016
標題: | Associations between high-sensitivity C-reactive protein and non-communicable diseases in an Asian population: findings from the IFLS study | 作者: | Juber, Nirmin CHIEN-CHANG LEE Liu, Jason J |
關鍵字: | Asian; C-reactive protein; epidemiology; hs-CRP; inflammation; non-communicable diseases | 公開日期: | 九月-2021 | 卷: | 26 | 期: | 6 | 來源出版物: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals | 摘要: | Background: There has been no comprehensive study on how high-sensitivity C-reactive protein (hs-CRP) levels, a biomarker of inflammation, are associated with subsequent diagnoses of various non-communicable diseases (NCDs) in Asians. Our study is the first to do so to better compare these associations in an Asian population.Methods: This is a nationwide longitudinal study of 3,410 male and 4,004 female participants of the RAND Indonesian Family Life Survey with a mean age of 42.4 years, to examine associations between increasing hs-CRP levels and risks of heart diseases, stroke, hypertension, diabetes, arthritis, non-cancerous stomach or other digestive diseases, and non-cancerous kidney diseases. We used unadjusted and confounding-adjusted weighted Poisson regression models to respectively examine associations involving hs-CRP as a risk predictor or indicator of chronic inflammation. Several stratified subpopulation analyses were also performed.Results: Increasing hs-CRP levels predicted significantly higher risks of being diagnosed with all of the studied NCDs except stomach or other digestive diseases. After adjusting for confounding, increasing hs-CRP levels were significantly associated with higher risks of diabetes, heart diseases, hypertension, and kidney diseases.Conclusions: Our comprehensive findings on the associations between hs-CRP levels and risks of several NCDs in Asians may have clinical implications and promote additional studies on this topic. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/586016 | ISSN: | 1354750X | DOI: | 10.1080/1354750X.2021.1936177 | SDG/關鍵字: | C reactive protein; C reactive protein; adult; arthritis; Article; cerebrovascular accident; chronic inflammation; controlled study; diabetes mellitus; female; gastrointestinal disease; heart disease; human; hypertension; Indonesian; kidney disease; longi |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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