Investigating the impact of probiotic on neurological outcomes in Rett syndrome: A randomized, double-blind, and placebo-controlled pilot study
Journal
Autism : the international journal of research and practice
Journal Volume
28
Journal Issue
9
Start Page
2267
End Page
2281
Date Issued
2024-02-15
Author(s)
Hsu, Chia-Jui
Chu, Hsu-Feng
JUI-HSIANG LIN
Wang, Hsin-Pei
Hu, Su-Ching
Tsai, Ying-Chieh
Abstract
Rett syndrome often involves gastrointestinal symptoms and gut microbiota imbalances. We conducted a study to explore the feasibility of probiotic Lactobacillus plantarum PS128 and the impact on neurological functions in Rett syndrome. The results of our investigation demonstrated that the supplementation of probiotic L. plantarum PS128 was feasible and well tolerated, with 100% retention rate and 0% withdrawal rate. In addition, there was only one participant who had loose stool after taking L. plantarum PS128. Further, there was a tendency to enhance overall cognitive developmental level, as assessed using Mullen Scales of Early Learning. In addition, it significantly improved dystonia, as assessed using the Burke-Fahn-Marsden Movement Scale, in comparison with the placebo group. This study provides a strong foundation for future research and clinical trials exploring the potential of L. plantarum PS128 probiotics as a complementary therapy for individuals with Rett syndrome.
Subjects
Rett syndrome; dystonia; microbiota–gut–brain axis; probiotics
Type
journal article