https://scholars.lib.ntu.edu.tw/handle/123456789/641463
標題: | Investigating the impact of probiotic on neurological outcomes in Rett syndrome: A randomized, double-blind, and placebo-controlled pilot study | 作者: | LEE-CHIN WONG Hsu, Chia-Jui Wu, Yen-Tzu Chu, Hsu-Feng JUI-HSIANG LIN Wang, Hsin-Pei Hu, Su-Ching Tsai, Ying-Chieh WEN-CHE TSAI WANG-TSO LEE |
關鍵字: | Rett syndrome; dystonia; microbiota–gut–brain axis; probiotics | 公開日期: | 15-二月-2024 | 來源出版物: | Autism : the international journal of research and practice | 摘要: | Rett syndrome often involves gastrointestinal symptoms and gut microbiota imbalances. We conducted a study to explore the feasibility of probiotic Lactobacillus plantarum PS128 and the impact on neurological functions in Rett syndrome. The results of our investigation demonstrated that the supplementation of probiotic L. plantarum PS128 was feasible and well tolerated, with 100% retention rate and 0% withdrawal rate. In addition, there was only one participant who had loose stool after taking L. plantarum PS128. Further, there was a tendency to enhance overall cognitive developmental level, as assessed using Mullen Scales of Early Learning. In addition, it significantly improved dystonia, as assessed using the Burke-Fahn-Marsden Movement Scale, in comparison with the placebo group. This study provides a strong foundation for future research and clinical trials exploring the potential of L. plantarum PS128 probiotics as a complementary therapy for individuals with Rett syndrome. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641463 | ISSN: | 13623613 | DOI: | 10.1177/13623613231225899 |
顯示於: | 醫學系 |
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