A precious experience of lobar transplantation in a teenager with end-stage chronic hypersensitivity pneumonia: Case report
Journal
Transplantation Proceedings
Journal Volume
36
Journal Issue
8
Pages
2399-2402
Date Issued
2004
Author(s)
Abstract
Pulmonary fibrosis inevitably develops in patients with chronic hypersensitivity pneumonia (CHP). Lobar transplantation may be a viable option for pediatric and small adult patients with end-stage CHP and life-threatening respiratory decompensation. We describe a 16-year-old girl experiencing end-stage pigeon breeder's hypersensitivity pneumonia with right heart failure, who received left allograft lobar transplantation and had an uneventful convalescent course for 1 year after transplantation. Histopathologically the excised native lung revealed diffuse infiltration of lung parenchyma by CD3 + and CD8 + cells with an absence of CD4 + cells, whereas T-lymphocyte subsets analysis revealed no abnormalities in the blood. This finding is consistent with the contribution of a local type IV immune reaction to the pathogenesis. In addition, the observation of specific cellular distribution of bronchus-associated lymphoid tissue suggests that chronic antigenic stimulation and /or inflammation in CHP may cause bronchus-associated lymphoid tissue development, which is likely to play an important role in the mucosal immune response of this disease.
SDGs
Other Subjects
CD3 antigen; CD4 antigen; CD8 antigen; adolescent; allergic pneumonitis; allograft; blood analysis; case report; cell infiltration; cellular distribution; conference paper; convalescence; disease course; female; heart right ventricle failure; histopathology; human; immunity; inflammation; lung lobe; lung parenchyma; lung transplantation; lymphoid tissue; mucosal immunity; pathogenesis; pigeon breeder lung; priority journal; T lymphocyte subpopulation; Adolescent; Animals; Columbidae; Female; Humans; Hypersensitivity; Lung Transplantation; Pneumonia; Radiography, Thoracic
Type
conference paper