https://scholars.lib.ntu.edu.tw/handle/123456789/473917
標題: | A precious experience of lobar transplantation in a teenager with end-stage chronic hypersensitivity pneumonia: Case report | 作者: | YIH-LEONG CHANG CHEN-TU WU PEI-MING HUANG Shu H.-S. Lee Y.-C. |
公開日期: | 2004 | 卷: | 36 | 期: | 8 | 起(迄)頁: | 2399-2402 | 來源出版物: | Transplantation Proceedings | 摘要: | Pulmonary fibrosis inevitably develops in patients with chronic hypersensitivity pneumonia (CHP). Lobar transplantation may be a viable option for pediatric and small adult patients with end-stage CHP and life-threatening respiratory decompensation. We describe a 16-year-old girl experiencing end-stage pigeon breeder's hypersensitivity pneumonia with right heart failure, who received left allograft lobar transplantation and had an uneventful convalescent course for 1 year after transplantation. Histopathologically the excised native lung revealed diffuse infiltration of lung parenchyma by CD3 + and CD8 + cells with an absence of CD4 + cells, whereas T-lymphocyte subsets analysis revealed no abnormalities in the blood. This finding is consistent with the contribution of a local type IV immune reaction to the pathogenesis. In addition, the observation of specific cellular distribution of bronchus-associated lymphoid tissue suggests that chronic antigenic stimulation and /or inflammation in CHP may cause bronchus-associated lymphoid tissue development, which is likely to play an important role in the mucosal immune response of this disease. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-9244246266&doi=10.1016%2fj.transproceed.2004.08.004&partnerID=40&md5=d09f84d2baca3e3ef34ab130a2866763 https://scholars.lib.ntu.edu.tw/handle/123456789/473917 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2004.08.004 | SDG/關鍵字: | CD3 antigen; CD4 antigen; CD8 antigen; adolescent; allergic pneumonitis; allograft; blood analysis; case report; cell infiltration; cellular distribution; conference paper; convalescence; disease course; female; heart right ventricle failure; histopathology; human; immunity; inflammation; lung lobe; lung parenchyma; lung transplantation; lymphoid tissue; mucosal immunity; pathogenesis; pigeon breeder lung; priority journal; T lymphocyte subpopulation; Adolescent; Animals; Columbidae; Female; Humans; Hypersensitivity; Lung Transplantation; Pneumonia; Radiography, Thoracic |
顯示於: | 病理學科所 |
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