Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose
Journal
Diabetologia
Date Issued
2021-04-12
Author(s)
Chung, Ren-Hua
Chiu, Yen-Feng
Wang, Wen-Chang
Hwu, Chii-Min
Hung, Yi-Jen
Lee, I-Te
Quertermous, Thomas
Rotter, Jerome I
Chen, Yii-Der I
Chang, I-Shou
Hsiung, Chao A
Abstract
An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in influencing the trait are unclear. This study aimed to identify the mediation effects of DNA methylation between SNPs identified as significant from GWAS and fasting glucose using Mendelian randomisation (MR) analyses.
Subjects
DNA methylation; Fasting glucose; GWAS; Han Chinese; Mendelian randomisation; Multi-omics analysis
SDGs
Other Subjects
glucose; glucose 6 phosphatase; glucose 6 phosphatase catalytic subunit 2; low density lipoprotein cholesterol; unclassified drug; 5' untranslated region; adult; Article; biobank; cohort analysis; CpG island; DNA methylation; DNA methylation assay; expres
Type
journal article