Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation
Journal
Journal of endodontics
Date Issued
2023-07-16
Author(s)
Hong, Chi-Yuan
Yang, Cheng-Ning
EDDIE HSIANG HUA LAI
Chen, Mu-Hsiung
Yang, Hsiang
Lin, Hung-Ying
Wu, Fang-Yu
Abstract
We have previously demonstrated that auxiliary metformin therapy promotes healing of apical periodontitis. Here we aimed to investigate the effects of metformin on osteoblast differentiation and osteoclast formation in cultured cells and rat apical periodontitis.
Subjects
Apical periodontitis; hypoxia; metformin; receptor activator of nuclear factor-κB ligand; runt-related transcription factor 2; tartrate-resistant acid phosphatase
Type
journal article