The estimation of cerebral metabolic rate of O2 from Near Infra-Red Spectroscopy
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Journal Volume
7 VOLS
Pages
3974-3977
Date Issued
2005
Author(s)
Payne S.J.
Abstract
The accurate estimation of cerebral metabolic rate of O2 (CMRO2) is still an unavailable but highly desired clinical tool. The addition of a further experimental variable to Near Infra-Red Spectroscopy (NIRS) allows more information to be gained than has previously been possible. A physiological model is presented here that can be used to estimate CMRO2 from measurements of oxy- and deoxy- haemoglobin and oxygen saturation. It is shown that under steady state conditions, CMRO2 can be estimated accurately, despite the system of equations being underdetermined, partly since the parameters that have to be provided are physiologically meaningful and thus unlikely to vary over a wide range. Initial simulations under dynamic conditions seem to support the hypothesis that dynamic changes in CMRO2 can also be estimated accurately, although this is still work in progress. ?2005 IEEE.
Subjects
Computer simulation
Information analysis
Parameter estimation
Physiological models
Spectroscopic analysis
Cerebral metabolic rate
Clinical tools
Haemoglobin
Oxygen saturation
Metabolism
Type
conference paper