A preliminary report of a low-dose step-up regimen of recombinant human FSH for young women undergoing ovulation induction with IUI
Journal
International Journal of Fertility and Sterility
Journal Volume
9
Journal Issue
4
Pages
436-441
Date Issued
2016
Author(s)
Abstract
Background: The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-FSH) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction (OI) with intrauterine insemination (IUI). Materials and Methods: The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan. In this prospective, observational study, consecutive infertile women (20-35 years) with regular menstrual cycles and a normal baseline FSH level were prospectively enrolled between January 2010 and September 2010. A starting dose of 112.5 IU/day r-FSH was administered on day 3 and increased by 37.5 IU/day every 2 days until a follicle ?11 mm in diameter was present. Recombinant human chorionic gonadotropin (r-hCG) was administered when a follicle ?18 mm was noted. Monifollicular development was defined as only one follicle with a diameter ?16 mm. Clinical pregnancy was defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs. Results: A total of 29 women and 30 cycles were included. The mean daily dose of r-FSH to achieve a follicle of ?11 mm in diameter was 131.3 ± 23.6 IU and the mean total dose was 1030.0 ± 383.2 IU. Approximately 41% of the cycles were monofollicular. Clinical pregnancy was observed in 9 (30.0%) cycles, and a fetal heart beat was observed in 7 (23.3%). There were no multiple pregnancies. Mild ovarian hyperstimulation syndrome, which was resolved with conservative management, was observed in 3 (10.0%) cycles. Conclusion: This r-FSH low-dose step-up regimen seems to be a feasible and practical method for OI in younger infertile women undergoing IUI. ? 2015, Royan Institute (ACECR). All rights reserved.
Subjects
Infertility; Ovarian hyperstimulation syndrome; Ovulation induction
SDGs
Other Subjects
chorionic gonadotropin; estradiol; follitropin; adult; Article; clinical article; conservative treatment; echography; endometrial thickness; female; female infertility; follow up; gestational sac; gynecologic bleeding; gynecologic disease; human; hysteroscopy; intrauterine insemination; menstrual cycle; observational study; ovary hyperstimulation; ovulation induction; pregnancy; prospective study; transvaginal echography; uterine tube
Type
journal article