https://scholars.lib.ntu.edu.tw/handle/123456789/454445
標題: | A preliminary report of a low-dose step-up regimen of recombinant human FSH for young women undergoing ovulation induction with IUI | 作者: | Lu H.-F Peng F.-S SHEE-UAN CHEN Chiu B.-C Yeh S.-H Hsiao S.-M. |
關鍵字: | Infertility; Ovarian hyperstimulation syndrome; Ovulation induction | 公開日期: | 2016 | 卷: | 9 | 期: | 4 | 起(迄)頁: | 436-441 | 來源出版物: | International Journal of Fertility and Sterility | 摘要: | Background: The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-FSH) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction (OI) with intrauterine insemination (IUI). Materials and Methods: The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan. In this prospective, observational study, consecutive infertile women (20-35 years) with regular menstrual cycles and a normal baseline FSH level were prospectively enrolled between January 2010 and September 2010. A starting dose of 112.5 IU/day r-FSH was administered on day 3 and increased by 37.5 IU/day every 2 days until a follicle ?11 mm in diameter was present. Recombinant human chorionic gonadotropin (r-hCG) was administered when a follicle ?18 mm was noted. Monifollicular development was defined as only one follicle with a diameter ?16 mm. Clinical pregnancy was defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs. Results: A total of 29 women and 30 cycles were included. The mean daily dose of r-FSH to achieve a follicle of ?11 mm in diameter was 131.3 ± 23.6 IU and the mean total dose was 1030.0 ± 383.2 IU. Approximately 41% of the cycles were monofollicular. Clinical pregnancy was observed in 9 (30.0%) cycles, and a fetal heart beat was observed in 7 (23.3%). There were no multiple pregnancies. Mild ovarian hyperstimulation syndrome, which was resolved with conservative management, was observed in 3 (10.0%) cycles. Conclusion: This r-FSH low-dose step-up regimen seems to be a feasible and practical method for OI in younger infertile women undergoing IUI. ? 2015, Royan Institute (ACECR). All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/454445 | ISSN: | 2008-076X | SDG/關鍵字: | chorionic gonadotropin; estradiol; follitropin; adult; Article; clinical article; conservative treatment; echography; endometrial thickness; female; female infertility; follow up; gestational sac; gynecologic bleeding; gynecologic disease; human; hysteroscopy; intrauterine insemination; menstrual cycle; observational study; ovary hyperstimulation; ovulation induction; pregnancy; prospective study; transvaginal echography; uterine tube |
顯示於: | 醫學系 |
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