Ceiling effect of clomiphene citrate on the testosterone to estradiol ratio in eugonadal infertile men
Journal
PloS one
Journal Volume
17
Journal Issue
1
Date Issued
2022
Author(s)
Abstract
The testosterone to estradiol ratio (T/E2 ratio) reportedly exerts a stronger effect on semen quality and sexual desire than does testosterone alone. Clomiphene citrate is a selective estrogen receptor modulator that has long been used as an empirical treatment option in the management of idiopathic oligozoospermia. Clomiphene may change the hypothalamus-pituitary-gonad axis and result in the alteration of the T/E2 ratio. No reliable data are available regarding the change in the T/E2 ratio after clomiphene use in eugonadism.
Subjects
SECONDARY HYPOGONADISM; THERAPY
SDGs
Publisher
PUBLIC LIBRARY SCIENCE
Type
journal article