Alterations in the foveal avascular zone and surrounding capillary network as important indicators of visual prognosis for hereditary macular dystrophy.
Journal
Taiwan journal of ophthalmology
Journal Volume
15
Journal Issue
3
Start Page
457
End Page
465
ISSN
2211-5072
Date Issued
2025
Author(s)
Lin, Yen-Ching
Ko, Ting-Chieh
Yang, Chang-Hao
Chen, Pei-Hsuan
Yang, Chung-May
Chen, Ta-Ching
Abstract
PURPOSE: Hereditary macular dystrophy (MD) usually severely affects the central vision. This study aimed to explore macular microcirculation and its relationship with disease progression in different morphological patterns of MD.
MATERIALS AND METHODS: Sixty‑five patients with MD and 26 healthy participants were included. Panel‑based next‑generation sequencing (NGS), fundus autofluorescence (FAF), and optical coherence tomography angiography (OCTA) were used for genetic diagnosis, morphological classification, and evaluation of macular microcirculation, respectively. Patients were divided into two groups: the central lesion group (CLG) and the dispersed lesion group (DLG), based on FAF findings. The alterations in microcirculation between the groups and subgroups were analyzed and correlated with visual preservation.
RESULTS: A high diagnostic rate of disease‑causing genes was achieved with a panel‑based NGS test (72.3%). Compromised macular microcirculation was seen in MD of all genotypes. Enlargement of the foveal avascular zone and decreased foveal vessel density was significantly correlated with impaired vision (both P < 0.05). In Stargardt disease, the CLG had an earlier onset than the DLG, with more severely impaired central vision and compromised microcirculation.
CONCLUSION: OCTA is a reliable, noninvasive tool for evaluating the microcirculation of MD. Our results demonstrate that compromised macular microcirculation occurs with MD, and foveal microcirculation is crucial for visual preservation. © 2025 Taiwan J Ophthalmol | Published by Wolters Kluwer - Medknow.
Subjects
Capillary network
Stargardt disease
foveal avascular zone
hereditary macular dystrophy
optical coherence tomography angiography
SDGs
Publisher
Wolters Kluwer Medknow Publications
Type
journal article