Familial tendency and risk of nasopharyngeal carcinoma in Taiwan: Effects of covariates on risk
Journal
American Journal of Epidemiology
Journal Volume
173
Journal Issue
3
Pages
292-299
Date Issued
2011
Author(s)
Hsu W.-L.
Yu K.J.
Chien Y.-C.
Cheng Y.-J.
Chen J.-Y.
Liu M.-Y.
Chou S.-P.
You S.-L.
Hong J.-H.
Leu Y.-S.
Tsai M.-H.
Su M.-C.
Tsai S.-T.
Chao W.-Y.
Ger L.-P.
Chen P.-R.
Yang C.-S.
Hildesheim A.
Diehl S.R.
Chen C.-J.
Abstract
In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses. ? 2010 The Author.
SDGs
Other Subjects
deoxyribonuclease; Epstein Barr virus antigen; immunoglobulin A; tumor marker; virus capsid antigen; cancer; carcinogen; cohort analysis; health risk; risk factor; smoking; virus; adult; article; cigarette smoking; cohort analysis; confidence interval; controlled study; disease predisposition; Epstein Barr virus; familial disease; family history; female; hazard ratio; human; major clinical study; male; nasopharynx carcinoma; serology; Taiwan; virus capsid; Adult; Antigens, Viral; Cohort Studies; Deoxyribonucleases; Family; Female; Genetic Predisposition to Disease; Herpesvirus 4, Human; Humans; Immunoglobulin A; Incidence; Male; Middle Aged; Nasopharyngeal Neoplasms; Proportional Hazards Models; Prospective Studies; Questionnaires; Registries; Risk Factors; Smoking; Taiwan; Tumor Markers, Biological; Viral Proteins; Taiwan; Herpesviridae; Human herpesvirus 4; Miridae
Type
journal article