https://scholars.lib.ntu.edu.tw/handle/123456789/518270
標題: | Familial tendency and risk of nasopharyngeal carcinoma in Taiwan: Effects of covariates on risk | 作者: | Hsu W.-L. Yu K.J. Chien Y.-C. CHUN-JU CHIANG Cheng Y.-J. Chen J.-Y. Liu M.-Y. Chou S.-P. You S.-L. Hsu M.-M. PEI-JEN LOU CHENG-PING WANG Hong J.-H. Leu Y.-S. Tsai M.-H. Su M.-C. Tsai S.-T. Chao W.-Y. Ger L.-P. Chen P.-R. Yang C.-S. Hildesheim A. Diehl S.R. Chen C.-J. |
公開日期: | 2011 | 卷: | 173 | 期: | 3 | 起(迄)頁: | 292-299 | 來源出版物: | American Journal of Epidemiology | 摘要: | In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses. ? 2010 The Author. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251497662&doi=10.1093%2faje%2fkwq358&partnerID=40&md5=3d518217365e0740fa7161c4ebe866f5 https://scholars.lib.ntu.edu.tw/handle/123456789/518270 |
ISSN: | 0002-9262 | DOI: | 10.1093/aje/kwq358 | SDG/關鍵字: | deoxyribonuclease; Epstein Barr virus antigen; immunoglobulin A; tumor marker; virus capsid antigen; cancer; carcinogen; cohort analysis; health risk; risk factor; smoking; virus; adult; article; cigarette smoking; cohort analysis; confidence interval; controlled study; disease predisposition; Epstein Barr virus; familial disease; family history; female; hazard ratio; human; major clinical study; male; nasopharynx carcinoma; serology; Taiwan; virus capsid; Adult; Antigens, Viral; Cohort Studies; Deoxyribonucleases; Family; Female; Genetic Predisposition to Disease; Herpesvirus 4, Human; Humans; Immunoglobulin A; Incidence; Male; Middle Aged; Nasopharyngeal Neoplasms; Proportional Hazards Models; Prospective Studies; Questionnaires; Registries; Risk Factors; Smoking; Taiwan; Tumor Markers, Biological; Viral Proteins; Taiwan; Herpesviridae; Human herpesvirus 4; Miridae |
顯示於: | 醫學系 |
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