A targeting self-breakable agent for increased efficacy of chemotherapeutic drugs against caco2 cells
Journal
9th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies
Pages
216-221
Date Issued
2016
Author(s)
URI
Abstract
Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self- Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment. ? 2016 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved.
Subjects
Caco2; Micelle; Sn38
SDGs
Other Subjects
Biomedical engineering; Controlled drug delivery; Covalent bonds; Diseases; Electronic medical equipment; Micelles; Sulfur compounds; Anti-cancer agents; Caco2; Chemotherapeutic agents; Chemotherapeutic drugs; Colon cancer cells; Controlled drug release; Disulfide bonds; Sn38; Targeted drug delivery
Publisher
SciTePress
Type
conference paper