https://scholars.lib.ntu.edu.tw/handle/123456789/465738
標題: | A targeting self-breakable agent for increased efficacy of chemotherapeutic drugs against caco2 cells | 作者: | Tsai M.-H. MING-JIUM SHIEH Peng C.-L. |
關鍵字: | Caco2; Micelle; Sn38 | 公開日期: | 2016 | 出版社: | SciTePress | 起(迄)頁: | 216-221 | 來源出版物: | 9th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies | 摘要: | Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self- Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment. ? 2016 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969822653&partnerID=40&md5=6ba13bd89c5b3089393910a394a521d3 https://scholars.lib.ntu.edu.tw/handle/123456789/465738 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969822653&doi=10.5220%2f0005766002160221&partnerID=40&md5=c14f31aa7468f126f675960e4f121a92 |
SDG/關鍵字: | Biomedical engineering; Controlled drug delivery; Covalent bonds; Diseases; Electronic medical equipment; Micelles; Sulfur compounds; Anti-cancer agents; Caco2; Chemotherapeutic agents; Chemotherapeutic drugs; Colon cancer cells; Controlled drug release; Disulfide bonds; Sn38; Targeted drug delivery |
顯示於: | 醫學工程學研究所 |
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